Introduction: Keloids are pathological scars that are notorious for their chronic and relentless invasion into adjacent healthy skin, with commonly seen post-therapeutic recurrence after monotherapies.Methods: An Cushion English literature review on keloid pathophysiology was performed by searching the PubMed, Embase and Web of Science databases, t

O artigo discute as estratégias metodológicas Cushion que vêm sendo usadas na análise das inter-relações entre a vulnerabilidade ao HIV/AIDS e as desigualdades sociais, o preconceito e a marginalização, ressaltando-se as dificuldades metodológicas e as estratégias alternativas de investigação encontradas.Os principais achados da literat

Abstract Background CDC6 is an oncogenic protein whose expression level fluctuates during the cell cycle.Although several E3 ubiquitin ligases responsible for the ubiquitin-mediated proteolysis of CDC6 have been identified, the deubiquitination pathway for CDC6 has not been investigated.Methods The proteome-wide deubiquitinase (DUB) screening was u

Abstract Background The knee joint performs mechanical functions with various loading and unloading processes.Past studies have focused on the kinematics and elastic response of the joint with less understanding of the rate-dependent load response associated with viscoelastic and poromechanical behaviors.Methods Forty-five fresh porcine knee joints